Are Exosomes the future of Aesthetic Medicine?

INNO EXOMA® EXO-SKIN

Exosomes have emerged as the most coveted “ingredient” in aesthetic medicine, despite not being an ingredient in the traditional sense.

These minuscule vesicles play a pivotal role in cell-to-cell communication and several physiological processes. However, due to safety concerns, the use of human cell-derived exosomes is primarily restricted to regenerative medicine in many countries. Nonetheless, numerous skincare brands claim to have found alternative types of exosomes that provide exceptional results.

But is this claim valid? Is all the buzz surrounding exosomes just a passing trend, or have they truly become a mainstay?

WHAT ARE EXOSOMES?

Exosomes are microscopic vesicles released by cells containing growth factors, cytokines, and genetic material. They transport this essential biological cargo from one cell to another and seamlessly enter the recipient cell to release their cargo inside. This biological information triggers a cascade of physiological reactions ultimately leading to tissue regeneration. More specifically, they promote cell proliferation, migration, and differentiation, ultimately boosting the formation of key tissue components and protein formation, leading to extraordinary regenerative effects.

They are widely used in regenerative medicine, but, as they contain genetic material, their use is limited by strict regulations. Indeed, exosomes can spread health, but they can also spread disease if coming from a sick cell.

INNO EXOMA® EXO-SKIN

Indication: Skin tissue regeneration.

Effects:

• Potent skin tissue regeneration activity that increases tissue homeostasis, thereby restoring physiological balance.  
• Improves skin texture.
• Increases dermal density.
• Enhances the quality of the connective tissue.
• Combats skin aging signs.  
• Reduces hair loss.

Mechanism of Action:  

Synthetic exosomes that act as a system for transporting amino acids and forming peptides. They are considered key regulatory elements for many biological processes, including regenerative and antiaging properties. One of the main features of skin aging is the decrease in tissue regeneration, process in which exosomes play a key role as they act like messengers. Some of the most relevant effects of this product are:

• Stimulation of the skin epidermal barrier regeneration thanks to increasing ceramide synthesis.  
• It reduces inflammation through downregulating cytokine levels.  
• Induce collagen and elastin synthesis, thus enhancing skin firmness and elasticity.    
• By acting as messengers, exosomes can induce cell differentiation through signalling neighbouring cells to induce the differentiation of keratinocytes and fibroblasts and activate epidermal cells including hair follicles.
• It provides high regenerative effects, fighting the signs of skin aging associated with decreased cellular regeneration.
• It promotes hair follicle regeneration by stimulating its activity through cellular interactions promoted by exosomes, thus stimulating hair growth, and reducing hair loss.